publications archive

2009
Peer-reviewed papers


1. Uwe Thissen, Suzan Wopereis, Sjoerd A. A. van den Berg, Ivana Bobeldijk, Robert Kleemann, Teake Kooistra, Ko Willems van Dijk, Ben van Ommen, Age K. Smilde. Improving the analysis of designed studies by combining statistical modelling with study design information. BMC Bioinformatics 2009, 10: 52

2. Bernini F, Freeman D, Groen A, Heeren J, Kalopissis A, Kronenberg F, Lindstedt K, Parini P, Schuster G, Tybjaerg Hansen A, Willems van Dijk K, von Eckardstein A. European Lipoprotein Club: report of the 31st ELC Annual Conference, Tutzing, 8-11 September 2008. Atherosclerosis. 2009. 205:41-7.

3. van Iterson M, 't Hoen PA, Pedotti P, Hooiveld GJ, den Dunnen JT, van Ommen B, Boer JM, Menezes RX. Relative power and sample size analysis on gene expression profiling data. BMC Genomics. 2009;10:439

4. van Schothorst EM, Flachs P, Franssen-van Hal NL, Kuda O, Bunschoten A, Molthoff J, Vink C, Hooiveld GJ, Kopecky J, Keijer J. Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet. BMC Genomics. 2009;10:110.

5. van Baarlen P, Troost FJ, van Hemert S, van der Meer C, de Vos WM, de Groot PJ, Hooiveld GJ, Brummer RJ, Kleerebezem M. Differential NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance. Proc Natl Acad Sci U S A. 2009;106:2371-6.

6. Wopereis S, Rubingh CM, van Erk MJ, Verheij ER, van Vliet T, Cnubben NH, Smilde AK, van der Greef J, van Ommen B, Hendriks HF. Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes 2009. PLoS ONE, 4(2):e4525.

7. Henneman P, van der Sman-de Beer F, Moghaddam PH, Huijts P, Stalenhoef AF, Kastelein JJ, van Duijn CM, Havekes LM, Frants RR, Willems van Dijk K, Smelt AH.The expression of type III hyperlipoproteinemia: involvement of lipolysis genes. Eur J Hum Genet. 2009. 17:620-8

8. Henneman P, Janssens AC, Zillikens MC, Frolich M, Frants RR, Oostra BA, van Duijn CM, Willems van Dijk K. Menopause impacts the relation of plasma adiponectin levels with the metabolic syndrome. J Intern Med. 2009 Aug 26.

9. Voshol PJ, Rensen PC, Willems van Dijk K, Romijn JA, Havekes LM. Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: Studies using genetically engineered mouse models. Biochim Biophys Acta. 2009. 1791:479-85.

10. Verschuren L, Kooistra T, Bernhagen J, Voshol PJ, Ouwens DM, van Erk M, de Vries-van der Weij J, Leng L, van Bockel JH, Willems van Dijk K, Fingerle-Rowson G, Bucala R, Kleemann R. MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease. Circ Res. 2009. 105:99-107.

11. Bijland S, van den Berg SA, Voshol PJ, van den Hoek AM, Princen HM, Havekes LM, Rensen PC, Willems van Dijk K. CETP does not affect triglyceride production or clearance in APOE*3-leiden mice. J Lipid Res. 2009 Jun 29.

12. Radonjic M, de Haan JR, van Erk MJ, Willems van Dijk K, van den Berg SA,
de Groot PJ, Müller M, van Ommen B. Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program. PLoS One. 2009 Aug 14;4(8):e6646.

13. Castagnini C, Luceri C, Toti S, Bigagli E, Caderni G, Femia AP, Giovannelli L, Lodovici M, Pitozzi V, Salvadori M, Messerini L, Martin R, Zoetendal EG, Gaj S, Eijssen L, Evelo CT, Renard CM, Baron A, Dolara P. Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols. Br J Nutr. 2009 Jul 22:1-9

14. Bragt MC, Plat J, Mensink M, Schrauwen P, Mensink RP. Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFkappaB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus. BMC Endocr Disord. 2009 Feb 25;9:8.

15. Vrolix R, Mensink RP. Variability of the glycemic response to single food products in healthy subjects. Contemp Clin Trials. 2009 Sep 6

16. Hommelberg PP, Plat J, Langen RC, Schols AM, Mensink RP. Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. Am J Physiol Endocrinol Metab. 2009; 296:E114-20.

17. Timmers S, de Vogel-van den Bosch J, Towler MC, Schaart G, Moonen-Kornips E, Mensink RP, Hesselink MK, Hardie DG, Schrauwen P. Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation. J Lipid Res. 2009 Aug 18.

18. Volman JJ, Mensink RP, Buurman WA, Onning G, Plat J. The absence of functional dectin-1 on enterocytes may serve to prevent intestinal damage. Eur J Gastroenterol Hepatol. 2009 Aug 28.

19. Dullens SP, Mensink RP, Mariman EC, Plat J. Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine. Eur J Gastroenterol Hepatol. 2009; 21:642-9.

20. Theuwissen E, Plat J, Mensink RP. Consumption of oat ß-glucan with or without plant stanols did not influence inflammatory markers in hypercholesterolemic subjects. Molecular Nutrition & Food Research 2009; 53:370-6.

21. Mariman EC. 2DE-proteomics meta-data indicate the existence of distinct cellular stress-responsive mechanisms. Expert Rev Proteomics. 2009;6:337-9.

22. Wang P, Bouwman FG, Mariman EC. Generally detected proteins in comparative proteomics--a matter of cellular stress response? Proteomics. 2009 Jun;9(11):2955-66.

23. Crosley LK, Duthie SJ, Polley AC, Bouwman FG, Heim C, Mulholland F, Horgan G, Johnson IT, Mariman EC, Elliott RM, Daniel H, de Roos B. Variation in protein levels obtained from human blood cells and biofluids for platelet, peripheral blood mononuclear cell, plasma, urine and saliva proteomics. Genes Nutr. 2009 Jun;4(2):95-102.

24. Heidema AG, Thissen U, Boer JM, Bouwman FG, Feskens EJ, Mariman EC.
The association of 83 plasma proteins with CHD mortality, BMI, HDL-, and
total-cholesterol in men: applying multivariate statistics to identify proteins
with prognostic value and biological relevance. J Proteome Res. 2009 Jun;8(6):2640-9.

25. Augustin Scalbert, Lorraine Brennan, Oliver Fiehn, Thomas Hankemeier, Bruce S. Kristal, Ben van Ommen, Estelle Pujos, Elwin Verheij, David Wishart and Suzan Wopereis - Mass-spectrometry-based metabolomics in nutrition – Current limitations and recommendations – Metabolomics 2009, DOI 10.1007/s11306-009-0168-0

26. Marijana Radonjić, Marjan van Erk, Heleen Wortelboer, Wilrike Pasman, Henk Hendriks, Ben van Ommen - Effect of body fat distribution on the transcription response to a dietary fat intervention - Genes and Nutrition 2009 DOI 10.1007/s12263-009-0122-9

27. Ulrich Harttig, Anthony J. Travis, Philippe Rocca-Serra, Marten Renkema, Jolande Boer, Ben van Ommen and Heiner Boeing - Data exchange and data integration in nutrigenomic collaborations – The NuGO information network. – Genes and Nutrition 2009 DOI 10.1007/s12263-009-0123-8.

28. Ben van Ommen, Jaap Keijer, Sandra Heil and Jim Kaput - Challenging homeostasis to define biomarkers for individual nutrition related health – Molecular Nutrition and Food Research 2009 795-804 53

29. Bobeldijk, S. Wopereis, C. Rubingh, F. van der Kloet, H. Hendriks, E. Verheij and B. van Ommen. Metabolomics in human nutrition studies. 2009 In: Design of human studies, Wageningen Academic Publishers, the Netherlands.

30. Leon Coulier, Suzan Wopereis, Henk Hendriks, Marijana Radonjic and Renger Jellema. Applied chemometrics in systems biology and nutritional metabolomics. Applications: systems biology. 2009. In: Comprehensive chemometrics. volume 4, pp. 279-312 Oxford: Elsevier

31. Giebeler A, Boekschoten MV, Klein C, Borowiak M, Birchmeier C, Gassler N, Wasmuth HE, Müller M, Trautwein C, Streetz KL. c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice. Gastroenterology. 2009; 137: 297-308

32. Kersten S, Lichtenstein L, Steenbergen E, Mudde K, Hendriks HF, Hesselink MK, Schrauwen P, Müller M. Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids. Arterioscler Thromb Vasc Biol. 2009 Jun; 29:969-74

33. Bouwens M, van de Rest O, Dellschaft N, Bromhaar MG, de Groot LC, Geleijnse JM, Müller M, Afman LA. Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells.
Am J Clin Nutr. 2009 Aug; 90:415-24

34. Kersten S, Müller M. Dropping liver fat droplets. Hepatology 2009 Aug;50(2):645-7

35. Biesalski HK, Dragsted LO, Elmadfa I, Grossklaus R, Müller M, Schrenk D, Walter P, Weber P. Bioactive compounds: Definition and assessment of activity. Nutrition. 2009 Aug 18

36. Rakhshandehroo M, Hooiveld G, Müller M, Kersten S. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. Plos ONE 2009 Aug 27;4(8):e6796.

37. Afman L and Müller M. Transcriptomics applications in human nutrigenomics studies pp 15-20; In “Design of human nutrigenomics studies” edited by: Sian Astley and Linda Penn 2009, 104 pages. Wageningen Academic Publishers ISBN: 978-90-8686-094-4.

38. Albert A. de Graaf, Andreas .P Freidig, Baukje De Roos. Needa Jamsheedi, Mathias Heinemann, Ton A.C. Rullmann, Kevin Hall, Martin Adiels, Ben van Ommen. Nutritional systems biology modeling: from molecular mechanisms to physiology – PloS Computational Biology, 2009, e1000554

39. Daniël B. van Schalkwijk, Ben van Ommen, Kees van Bochove, Patrick C.N. Rensen, Louis M. Havekes, Niek C.A. van de Pas, Albert A. de Graaf, Huub C. J. Hoefsloot, Jan van der Greef and Andreas Freidig - Improved cholesterol phenotype analysis by a model relating lipoprotein lifecycle processes to particle size – Journal of Lipid Research, 2009, 50: 2398–2411.

40. Ulrich Harttig, Anthony J. Travis, Philippe Rocca-Serra, Marten Renkema, Jolande Boer, Ben van Ommen and Heiner Boeing - Data exchange and data integration in nutrigenomic collaborations – The NuGO information network. – Genes and Nutrition, 2009 DOI 10.1007/s12263-009-0123-8.

41. De Wilde J, Smit E, Snepvangers FJM, Mohren R, Hulshof MFM, Mariman ECM. In vitro and in vivo regulation of adipophilin protein expression: a possible protective role against insulin resistance. Febs J. Epub 22 december 2009.

42. Zillikens MC, Uitterlinden AG, van Leeuwen JP, Berends AL, Henneman P, Willems van Dijk K, Oostra BA, van Duijn CM, Pols HA, Rivadeneira F. The Role of Body Mass Index, Insulin, and Adiponectin in the Relation Between Fat Distribution and Bone Mineral Density. Calcif Tissue Int. 2009 Dec 3

43. Sanderson L, Degerhardt T, Desvergne B, Koppen A, Kalkhoven E, Müller M, Kersten S. (2009) FFA regulate hepatic gene expression via PPARβ/δ but not PPARα. Mol. Cell. Biol. 29:6257-67

44. Kersten S, Bensadoun A.(2009) Stabilizing lipoprotein lipase. J. Lipid Res.
Aug 6.

45. Jeninga EH, Bugge A, Nielsen R, Kersten S, Hamers N, Dani C, Wabitsch M, Berger R, Stunnenberg HG, Mandrup S, Kalkhoven E. (2009) PPARgamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81). J Biol Chem. 2009 Jul 24

46. Brüll F, Mensink RP, van den Hurk K, Duijvestijn A, Plat J. TLR2 activation is essential to induce a TH1 shift in human PBMCs by plant stanols and plant sterols. Journal of Biological Chemistry 2009

47. Volman JJ, Helsper JP, Wei S, Baars JJ, van Griensven LJ, Sonnenberg AS, Mensink RP, Plat J. Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: Can effects be explained by structure? Molecular Nutrition & Food Research 2009

48. Plat J, Mensink RP. Plant stanol esters lower serum triacylglycerol concentrations via a reduced hepatic VLDL-1 production. Lipids 2009; 44:1149-1153.

49. Theuwissen E, Plat J, van der Kallen CJ, van Greevenbroek MM, Mensink RP. Plant stanol supplementation decreases serum triacylglycerols in subjects with overt hypertriglyceridemia. Lipids 2009; 44:1131-1140.

50. Schiepers OJ, de Groot RH, van Boxtel MP, Jolles J, de Jong A, Lütjohann D, Plat J, Mensink RP. Consuming functional foods enriched with plant sterol or stanol esters for 85 weeks does not affect neurocognitive functioning or mood in statin-treated hypercholesterolemic individuals. Journal of Nutrition 2009; 139:1368-1373.

51. Plat J, Brufau G, Dallinga-Thie GM, Dasselaar M, Mensink RP. A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients. Journal of Nutrition 2009; 139:1143-1149.

52. Mensink RP, Nestel P. Trans fatty acids and cardiovascular risk markers: does the source matter? Current Opinion in Lipidology 2009; 20:1-2.

53. Van Schothorst EM, Bunschoten A, Schrauwen P, Mensink RP, Keijer J. Effects of a high-fat, low- versus high-glycemic index diet: retardation of insulin resistance involves adipose tissue modulation. FASEB Journal 2009; 23:1092-1101.

54. Berendschot TT, Plat J, de Jong A, Mensink RP. Long-term plant stanol and sterol ester-enriched functional food consumption, serum lutein/zeaxanthin concentration and macular pigment optical density. British Journal of Nutrition 2009; 101:1607-1610.

55. Koeijvoets KC, van der Net JB, Dallinga-Thie GM, Steyerberg EW, Mensink RP, Kastelein JJ, Sijbrands EJ, Plat J. ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia. Atherosclerosis 2009; 204:453-458.

56. Malpuech-Brugère C, Morio B, Mensink RP. Dietary trans fatty acids and cardiovascular disease risk. In: Destaillats F, Sébédio JL, F. Dionisi F, Chardigny JM, eds. Trans fatty acids in human nutrition. Bridgwater: The Oily Press; 2009: 307-316. (ISBN: 978-0-9552512-3-8)

57. Cavalieri D, Calura E, Romualdi C, Marchi E, Radonjic M, Van Ommen B, Müller M. Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis. BMC Genomics. 2009 Dec 11;10:596.

58. Lu Y, Feskens EJ, Boer JM, Müller M. The potential influence of genetic variants in genes along bile acid and bile metabolic pathway on blood cholesterol levels in the population. Atherosclerosis. 2009 Nov 5.

59. van Dijk SJ, Feskens EJ, Bos MB, Hoelen DW, Heijligenberg R, Bromhaar MG, de Groot LC, de Vries JH, Müller M, Afman LA. A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome. Am J Clin Nutr. 2009;90:1656-64

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2008
Peer-reviewed papers
 

  • Bouwens M, Afman LA, Müller M
    Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual response
    BMC Genomics. 2008 Jun 2;9(1):262
  • De Wilde J, Mohren R, Van den Berg S, Boekschoten M, Willems van Dijk K, De Groot P, Müller M, Mariman E, and Smit E (2008)
    Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice. Physiological Genomics 32, 360-369.
  • De Vogel-Van den Bosch HM, De Wit NJW, Hooiveld GJEJ, Bosch-Vermeulen H, VanderVeen JN, Houten SM, Kuipers F, Müller M, and Van der Meer R (2008)
    A cholesterol free, high-fat diet auppresses gene expression of cholesterol transporter genes in murine small intestine. American Journal of Physiology - Gastrointestinal and Liver Physiology 294, 1171-1180.
  • De Vogel-van den Bosch HM, Bünger M, de Groot PJ, Bosch-Vermeulen H, Hooiveld GJ, Müller M
    PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression.
    BMC Genomics 2008, 9:231
  • De Wit NJW, Bosch-Vermeulen H, DeGroot PJ, Hooiveld GJE, GrootteBromhaar MM, Jansen J, Müller M, and VanderMeer R (2008)
    The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice. BMC Medical Genomics 1, 14-0 .
  • Herrema H, Derks TGJ, van Dijk TH, Bloks VW, Gerding A, Havinga R, Tietge UJF, Müller M, Smit PA, Kuipers F, Reijngoud DJ
    Disturbed Hepatic Carbohydrate Management During High Metabolic Demand in Medium-Chain Acyl-CoA Dehydrogenase (MCAD)-Deficient Mice. Hepatology 2008 Jun;47(6):1894-904
  • Rahkshandehroo M, Stienstra R, Carlberg C, De Groot PJ, and Müller M (2008)
    Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR research doi:10.1155/2007/26839, 0 .
  • Sanderson LM de Groot PJ, Hooiveld GJEJ, Koppen A, Kalkhoven E, Müller M, Kersten S
    Effect of Synthetic Dietary Triglycerides: a Novel Research Paradigm for Nutrigenomics PLOS ONE 2008 27;3(2):e1681.
  • Stienstra R, Duval C, Keshtkar S, van der Laak J, Kersten S, Müller M
    PPARgamma activation promotes infiltration of alternatively activated macrophages into adipose tissue. Journal of Biological Chemistry 283; 22620–22627
  • Van Ommen B, Keijer J, Kleemann R, Elliott R, Drevon CA, McArdle H, Gibney G, and Müller M (2008)
    The challenges for molecular nutrition research 2: quantification of the nutritional phenotype. Genes and Nutrition 3, 4149.

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Posters
 

  • Bragt MCE, Plat J, Mensink M, Schrauwen P, and Mensink RP
    The effect of Rosiglitazone on inflammatory markers and NFkappaB-related genes in type II diabetic subjects. Keystone, 27-1-2008 . Breckenbridge, Co, USA.
  • De Wit N, Bosch-Vermeulen H, Oosterink E, Müller M, and Van der Meer R
    Dietary calcium does not protect against dietary fat-induced obesity and insulin resistance in C57Bl/6j mice. FASEB Summer Research Conference 2008: Molecular Mechanisms Involved in the Nutrient Control of Cellular Function, 25-7-2008 . Carefree, Arizona, USA.
  • Duval C, Boekschoten M, Keshtkar S, DeGroot P, Jansen J, Roskams T, Kersten S, and Müller M
    eWat failure signals the evolution of NAFLD towards NASH in the C56BL/6 dio model. Keystone, 27-1-0200 . Beckenbridge Co, USA.
  • Popeijus HE and Mensink RP
    Human stearoyl-Coenzyme A desaturase 1 linked to insulin signalling? Keystone, 27-1-2008 . Breckenbridge, Co, USA.
  • Radonjic M, van Erk M, Willems van Dijk K, van de Berg S, and Van Ommen B
    Genome-wide mRNA expression analysis of high-fat induced hepatic pathophysiology in ApoE3*L mice. Systems Biology: Global Regulation of Gene Expression, 30-3-2008 . Cold Spring Harbor, USA.
  • Rakhshandehroo M, Müller M, and Kersten S
    The PPARa dependent transcriptome in primary human hepatocytes. Symposium CIG metabolism and cancer, 3-6-2008 . Lausanne, Switzerland.

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2007
Peer-reviewed papers
 

  • Bouwens M, Afman L, and Müller M (2007)
    Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation. A functional role of PPAR alpha in human peripheral blood mononuclear cell. American Journal of Clinical Nutrition 86, 1515-1523 .
  • Bünger M, Van den Bosch HM, Van der Meijde J, Kersten S, Hooiveld GJ, and Müller M (2007)
    Genome-wide analysis of PPAR-alpha activiation in murine small intestine. Physiological Genomics 30, 192-204 .
  • Bünger M, Hooiveld GJ, Kersten S, and Müller M (2007)
    Exploration of PPAR functions by microaray tehnology-A paradignm for nutrigenomics. Biochimica et Biophysica Acta-General Subjects 1771, 1046-1064
  • Duval C, Müller M, and KerstenS. (2007)
    PPAR-alpha and dyslipidemia. Biochimica et Biophysica Acta-General Subjects 1771, 961-971 .
  • Gaj S, VanErk A, Van Haaften RIM, and Evelo CTA (2007)
    Linking microarray reporters to protein functions. BMC Genomics 8, 267 .
  • Lichtenstein L, Berbee JF, Van Dijk S, Blijland S, Willems van Dijk K, Voshol PJ, Müller M, and Rensen PCN (2007)
    Angptl4 up-regulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Arteriosclerosis Thrombosis and Vascular Biology 27, 2420-2427 .
  • Mandard S, Stienstra R, Escher P, Tan NS, Kim I, Gonzalez FJ, Wahli W, Desvergne B, Müller M, and Kersten S (2007)
    Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors. Cellular and Molecular Life Sciences 64, 1145-1157 .
  • Stienstra R, Mandard S, Tan NS, Wahli W, Trautwein C, RichardsonT.A., Lichtenauer-Kaligis E, Kersten S, and Müller M (2007)
    The interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Journal of Hepatology 46, 869-877 .
  • Stienstra R, Mandard S, Patsouris D, Maass C, Kersten S, and Müller M (2007)
    Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation. Endocrinology 148, 2753-2763.
  • Van den Bosch HM, Bünger M, De Groot PJ, Van der Meijde J, Hooiveld GJ, and Müller M (2007)
    Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting. BMC Genomics 8, 267

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Invited lectures at international conferences
 

  • Kersten S
    Role of PPARalpha in fatty acid sensing. 10th FENS conference, 13-7-2007 . Paris, France.
  • Kersten S
    The role of PPARs as fatty acid sensors controlling metabolism and inflammation.Fall meeting Dutch Society for Gastroenterology, 1-10-2007 . Veldhoven, the Netherlands.
  • Kersten S
    Regulation of metabolism by PPARalpha and Angiopoietin-like protein4. Brigham and Women's Hospital, Harvard Medical School, 1-10-2007 . Harvard, USA.
  • Kersten S
    Nutrigenomics. Nutrition Conference 2007, 12-12-2007 . Bangkok, Thailand.
  • Kersten S
    Transgenic mice in nutrigenomics research. Masterclass Nutrigenomics, Wageningen University, 11-11-2007 . Wageningen, the Netherlands.
  • Kersten S
    Regulation of metabolism by PPARalpha and Angiopoitein-like protein 4. Centre Intqgrative de Gqnomique, Universitq de Lausanne, 11-11-2007 . Lausanne, Switzerland.
  • Kersten S
    Angiopoetin-like proteins in glucose and lipid metabolism, from mice to men. 3rd annual HDL symposium on Diabetic Sylipidemia, 9-2-2007 . Rotterdam, the Netherlands.
  • Mensink RP
    Health aspects of trans fatty acids. NZO/EDA Expert meeting on TFA & CLA, 4-5-2007 . Amsterdam, The Netherlands.
  • Mensink RP
    Defining the optimal fatty acid profile for the human diet: the role of saturated fatty acids. Canadian Nutrition Congress, 21-6-2007 . Winnipeg, Canada.
  • Mensink RP
    Voeding, cholesterol en hart- en vaatziekten. Chemische kring, Eindhoven, The Netherlands.
  • Mensink RP
    Dairy products and their role in the metabolic syndrome. Campina Science Day "Dairy and the Circle of Life", Rotterdam.
  • Müller M
    State of the art lecture on Nutrigenomics. German Nutrition Congress, 9-3-2007 . Halle, Germany.
  • Müller M
    Nutrigenomics and system biology. NUGO Symposium "The Quantification of Health", 18-5-2007 . Cork, Ireland.
  • Müller M
    Gene regulation by fatty acids. Seefeld Proteomics Conference, 31-1-2007 . Seefeld, Austria.
  • Müller M
    Applications of microarray analysis in hepatology. Basic School of Hepatology of the European Association for Study of the Liver (EASL). Course 2: Cell signaling in the liver, 4-2-2007 . Lisbon, Portugal.
  • Müller M
    Transcriptiomics applications in Nutrigenomics. 10th FENS Nutrition, 13-7-2007 . Paris, France.
  • Müller M
    Systems biology of fatty acid sensing. Annual NUGO conference, 21-9-2007 . Oslo, Norway.
  • Müller M
    Nutrigenomics. Individualized Medicine in Complex Diseases, 23-6-2007 . Regensburg, Germany.
  • Müller M
    Genomics for robust cows. ID-Lelystad Symposium "Nutrigenomics", 8-6-2007 . Lelystad, the Netherlands.
  • Müller M
    The NUGO proof-of-principle study. NUGO meeting, 17-7-2007 . Mnnich, Germany.
  • Van Ommen B
    Systems Biology in the nutrition and health relationship. University of Graz symposium on nutrition and antioxidants, 17-10-2007 . Graz, Oostenrijk.
  • Van Ommen B
    Nutrigenomics as key driver for nutrition and health relationship. 1st Varna Nutrigenomics Conference, 18-10-2007 . Varna, Bulgarije.
  • Van Ommen B
    The targeted plasma proteome in personalized health and nutrition. XMAP symposium, Amsterdam, 8-10-2007 . Amsterdam, Nederland.
  • Van Ommen B
    How can NuGO revolutionize human nutrition research using "omics" approaches?NuGO Bioethics workshop, Oslo, 18-9-2007 . Oslo, Noorwegen.
  • Van Ommen B
    Can nutrigenomics lead us to prevention of obesity? Oresund Obesity conference, Kopenhagen, 2-10-2007 . Kopenhagen, Denemarken.
  • Van Ommen B
    Nutrigenomics and nutritional Systems biology in Europe. Nutrigenomics Seminar, Kuopio University, 3-12-2007 . Kuopio, Finland.
  • Van Ommen B
    Metabolomics in the quantification of the nutrition and health relationship.Workshop on nutritional metabolomics, 12-12-2007 . Clermont-Ferrand, Frankrijk.
  • Van Ommen B
    Metabolomics in the quantification of the nutrition and health relationship.Unilever symposium on nutritional metabolomics, 15-11-2007 . Vlaardingen, Nederland.
  • Van Ommen B
    Pharmacogenomics and nutrition: Insights in disease prevention. Novo Nordisk Diabetes Dialogue conference, 26-10-2007 . Lisbon, Portugal.
  • Van Ommen B
    Metabolomics in nutrition research. Friedman Nutrition Symposium, 30-10-2007 . Boston, USA.
  • Van Ommen B
    Perspectives in personalised nutrition in research and industrial applications.Bioinnovativ Munich, 18-2-2007 . Munchen, Duitsland.
  • Van Ommen B
    Nutritional systems biology. Molecular Medicine Congress, 24-3-2007 . Istanbul, Turkey.
  • Van Ommen B
    Nutritional metabolomics in the quantification of health. Conference " What we are and what we eat", Charlotte, 16-4-2007 . Charlotte, USA.
  • Van Ommen B
    Voeding van Topkwaliteit. Natuurkundig gezelschap Assen, 9-1-2007 . Assen, Nederland.
  • Van Ommen B
    Life Sciences in 2012? Hogeschool Utrecht workshop, 9-10-2007 . Utrecht, Nederland.
  • Van Ommen B
    Nutrigenomics, voeding voor jouw genetische profiel. Studium Generale, Utrecht, 12-11-2007 . Utrecht, Nederland.
  • Van Ommen B
    Metabolism as Key in nutrition research. Northern light conference, Waterloo, 22-6-2007 . Waterloo, Canada.
  • Van Ommen B
    Nutritional Systems Biology. 10th European Nutrition Conference, 12-7-2007 . Paris, France.
  • Van Ommen B
    Nutrigenomics - an overview. Leatherhead nutrigenomics symposium, London, 11-9-2007 . London, UK.
  • Van Ommen B
    New challenges for molecular nutrition research. EuroBio, Krakow, 26-4-2007 . Krakow, Polen.
  • Van Ommen B
    The nutritional phenotype database. Symposium "The quantification of health", Cork, 18-5-2007 . Cork, Ireland.
  • Van Ommen B
    Nutritional systems biology from theory to practice. Cambridge Healthtech Institute Beyond Genome Conference, San Francisco, 20-6-2007 . San Francisco, USA.

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Posters
 

  • De Groot PJ, Gavai A, Lin K, Neerincx P, Hooiveld G, Leunissen JAM, and Müller M
    Tools that NuGO makes available to you to analyse your NuGO microarrays. NuGO week, Oslo, Norway.
  • De Wilde J, Mohren R, Mariman E, and Smit E
    A high fat/low carbohydrate diet down-regulates genes involved in synthesis, processing and storage of fatty acids in skeletal muscle of mice.
  • Rahkshandehroo M
    The role of PPARalpha in the human liver. NUGO week. Oslo, Norway.
  • Sanderson L
    The effects of dietary fatty acids on hepatic gene expression are almost entirely mediated by PPARalpha. Keystone symposium: Nuclear Receptor Pathways to Metabolic Regulation. Steamboat Springs, Colorado , USA.
  • Thissen U, Wopereis S, Van Den Berg SAA, Bobeldijk I, Kleemann R, Kooistra T, Willems vanD ijk K, Van Ommen B, and Smilde A.K
    Relating functional genomic data to phenotypes: an improved approach for structured data. NuGO week. Oslo, Norway.
  • Thissen, U.; Rubingh, C.;Van Erk, M.J.
    Statistical data quality control in the light of biological relevance. NuGO week. Oslo, Norway.

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2006
Peer-reviewed papers
 

  • Afman L and Müller M (2006)
    Nutrigenomics: From Molecular Nutrition to Prevention of Disease. Journal of the American Dietetic Association 106, 569-576 .
  • Henneman P, Schaap GS, Havekes LM, Rensen PCN, Frants RR, VanTol A, Hattori H, Smelt AHM, and WillemsvanDijk K (2006)
    Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism. Atherosclerosis 193, 120-134 .
     

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Invited lectures at international conferences
 

  • Afman L
    Nutrigenomics - From stressed mice to prevention of disease. ALCUEFOOD nutrigenomics workshop, 13-11-2006 . Lisbon, Portugal.
  • Müller M
    Transciptomics analysis of fatty acid dependent gene regulation.Masterclass Nutrigenomics, 19-5-2006 . Maastricht, the Netherlands.
  • Müller M
    Nutrigenomics: From stressed mice to healthy humans. GUIDE-UMCG Summer meeting, 29-6-2006 . Groningen, the Netherlands.
  • Müller M
    Nutrigenomics: Scientific basis for individuality - challenges and (un)certainties. CSG conference "Genomics & Society: towards a socially robust science, 20-4-2006 . Amsterdam, the Netherlands.
  • Müller M
    Smart foods: Die young as late as possible. Nutrigenomics: From molecular nutrition to prevention of disease. Food for the healthy elderly, 27-1-2006 . Amsterdam, the Netherlands.
  • Müller M
    Nutrigenomics: from stressed mice to healthy humans. Unilever, Vlaardingen, the Netherlands.
  • Müller M
    Nutrigenomics; from stressed mice to healthy humans. DSM Nutritional Products, 3-4-2006 . Basel, Switzerland.
  • Müller M
    Nutrigenomics. Karolinska PhD Course, 16-6-2006 . Stockholm, Sweden.
  • Müller M
    Nutrigenomics: the scientific background. Annual meeting Dutch Nutrition Society, 19-10-2006 . Utrecht, The Netherlands.
  • Müller M
    Hepatic nuclear receptors and steatosis. Autumn meeting Dutch Society of Hepatology, 5-10-2006 . Veldhoven, the Netherlands.
  • Müller M
    Nutrigenomics; from stressed mice to healthy humans. DSM Nutritional Products, 3-4-2006 . Basel, Switzerland.
  • Müller M
    Fatty acids as potent regulators of gene transciption - a Nutrigenomics approach. 4th Euro Fed Lipid Congress, 3-10-2006 . Madrid, Spain.
  • Müller M
    Nutrigenomics - from molecular nutrition to prevention of disease. Functional food symposium, 13-10-2006 . Hongkong, China.
  • Müller M
    Nutrition related transcriptiome data analysis - from small signals to biological meaning. Benelux Bioinformatics Conference, 18-10-2006 . Wageningen, the Netherlands.
  • Van Ommen B
    A nutritional systems biology approach between inflammation and metabolic stress. The international conference on nutrigenomics and guth health, 1-5-2006 . Auckland, New Zealand.
  • Van Ommen B
    Nutritional systems biology. Bioperspectives im Fokus "Food for the Future", 26-4-2006 . Potsdam, Germany.
  • Van Ommen B
    Nutrigenomics and healthy nutrition. Vitafood International Conference, 10-5-2006 . Geneva, Switzerland.
  • Van Ommen B
    Nutrition, disease and molecular mechanisms using omics technologies.Nutrition Society Summer Meeting, 5-7-2006 . Aberdeen, UK.
  • Van Ommen B
    Nutritional Metabolomics in practice. Metabolomics Society 2nd Annual Conference, 29-6-2006 . Boston, USA.
  • Van Ommen B
    From nutrition to nutrigenomics and back again. LMC symposium on nutrigenomics, 15-3-2006 . Copenhagen, Danmark.
  • Van Ommen B
    The systems approach to personalized nutrition. Leatherhead conference on nutrigenomics, 20-2-2006 . London, UK.
  • Van Ommen B
    Nutrigenomics and nutrional systems biology in prevention of cardiovascular disease. Unilever Corporate workshop series, 18-1-2006 . Colworth, UK.
  • Van Ommen B
    The food and health relationship approached by nutritional systems biology. First Mage Circe Metabolic systems analysis conference, 26-3-2006 . Sabauida, Italy.
  • Van Ommen B
    Voeding van Topkwaliteit. Diligentia maatschappij ter bevordering van de natuurkunde, 20-3-2006 . The Hague, The Netherlands.
  • Van Ommen B
    Lipidomics in a large dietary intervention study. Joint Genome Canada - LMC workshop on nutrigenomics, 17-3-2006 . Roskilde, Danmark.

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Posters
 

  • De Groot P, Gavai A, Lin K, Lui Y, Hooiveld G, Leunissen J, and Müller M
    NuGO human and mouse microarray support. The (statistical) analysis pipeline. The Third European Nutrigenomics Conference, NuGO week 2006,. Oxford, U.K.
  • Gavai A, De Groot P, Lin K, Lui Y, Hooiveld G, Müller M, and Leunissen J
    MADMAX û Management and Analysis Database for MicroArray eXperiments.
    The Third European Nutrigenomics Conference, NuGO week 2006, Oxford, U.K.
  • De Wit N, Vermeulen H, Muller M, and Van der Meer R
    Analysis of small intestinal gene expression in C57Bl/6 mice revealed a protective effect of calcium on dietary fat induced cell proliferation.Digestive Disease Week, Los Angeles, USA.
  • De Wit N, Vermeulen H, and Müller M
    Gene expression patterns reveal biological processes that are influenced by dietary fat in small intestine of C57Bl/6 mice, developing metabolic synrome on
    a high fat diet. FASEB Summer Research Conferences. Tucson, USA.
  • De Wilde J, Mohren R, Mariman E, and Smit E
    A high fat/low carbohydrate diet down-regulates genes involved in synthesis, processing and storage of fatty acids in skeletal muscle of mice. The Third European Nutrigenomics Conference, NuGO week 2006,. Oxford, U.K.
  • Lichtenstein L, Müller M, and Kersten S
    Exploration of the fasting induced adipose factor as a marker for metabolic syndrome. NuGO PhD introduction Course. Munich, Germany.
  • Lichtenstein L, Müller M, and Kersten S
    Exploration of the fasting induced adipose factor as a marker for metabolic syndrome. NuGO PhD introduction Course,. Munich, Germany.
  • Lichtenstein L, Berbe J, Rensen P, Müller M, and Kersten S
    Regulation of plasma lipoprotein metabolism by ANGPTL4. Gordon Research Conferences - Lipoprotein Metabolism,. South Hadley, MA, USA.
  • Popeijus HE and Mensink RP
    SCD-1: a role in type 2 diabetes mellitus? NuGO week 2006, Oxford, United Kingdom.
  • Radonjic M, van Erk M, Wopereis S, Thissen U, Willems van Dijk KV, and Müller M
    The effect of high fat diets on development of metabolic syndrom inApoE3-Leiden mouse: a systems approach. Keystome symposium "Metabolic syndrome and Cardiovascular Risk", USA.
  • Van den Bosch H, De Wit N, Vermeulen H, Hooiveld G, Kuipers F, Müller M, and Van der Meer R
    A high fat diet down-regulates gene expression of cholesterol efflux transporters in the small intestine of mice. FASEB Summer Research Conferences, Tucson, USA.
  • Wopereis S, Thissen U, Boeldijk I, Havekes L, Müller M, and Van Ommen B
    Liver metabolomics in transgenic APOE3Leiden mice treated with different high fat diets. The Second Annual International Conference of the Metabolomics Society, Boston, U.S.A.

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2005
Peer-reviewed papers
 

  • Kaput J and Ordovas JM (2005)
    The case for strategic international alliances to harness nutritional genomics for public and personal health. British Journal of Nutrition 94, 623-632 .

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Invited lectures at international conferences
 

  • Müller M
    Nutrigenomics and computational biology. ILSI Nutrigenomics conference, 11-9-2005 . Singapore, Singapore.
  • Müller M
    Polyunsaturated fatty acids and immune response. ILSI Nutrigenomics conference, 9-12-2005 . Singapore, Singapore.
  • Müller M
    Nutrigenomics: Signals, sensors and stress signatures. NuGO Week, 13-9-2005 . Florence, Italy.
  • Müller M
    Assessing the heatlh effects of bioactive food components. NIH conference, 24-3-2005 . Bethesda MD, USA.
  • Müller M
    How genomics tools can help to understand liver pathology. Postgraduate course Europeanm Association for the Study of the Liver "Post-genome Medicine", 17-4-2005 . Paris, France.
  • Müller M
    Nutrigenomics: signals, stressors and stress signatures. Zodiac, 4-10-2005 . Wageningen, The Netherlands.
  • Müller M
    Nutrigenomics: from molecular nutrition to prevention of disease. Genomics Momentum 2005, 5-10-2005 . The Hague, The Netherlands.
  • Müller M
    Nutrigenomics: from molecular nutrition to prevention of disease. Plant GEMS 2005, 21-9-2005 . Amsterdam, The Netherlands.
  • Müller M
    Nutrigenomics: From molecular nutrtition to prevention of disease. NuGO conference "Personalized Nutrition", 4-11-2005 . Mallorca, Spain.
  • Müller M
    Nutrigenomics: from molecular nutrition to prevention of disease. 50th Meeting of the Italian Society for Biochemistry, 29-9-2005 . Rimini, Italy.

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Posters

 

  • Koks PD, Van Erk MJ, Thissen U, Afman L, Van Ommen B, and Müller M
    Methods for high throughput microarray data analysis of the ICN high dietary fat mouse study. NuGOweek,. Florence, Italy.
  • Afman LA, GrootteBromhaar MM, and Müller M
    Changes in gene expression patterns during the aetiology of diet-induced insulin resistance in mice. NuGOweek. Florence, Italy.
  • De Wit N, Vermeulen H, Afman L, VanderMeer R, and Muller M
    Microarray analysis of small intestinal gene expression modulations in C57Bl/6 mice developing metabolic syndrome on a high fat diet. NUGO Week, Florence, Italy.
  • Bragt MCE, Plat J, Greve JW, and Mensink RP
    Relationships between gene expression profiles in PBMCS and peripheral tissues. NuGOweek Florence, Italy.
  • Gaj S, Evelo CTA, and Mensink RP
    Effect of short-term dietary interventions on molecular signatures in man.2nd NUGOweek, Florence, Italy.

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