our achievements
- Set-up and validation of Oracle-based LIMS database Madmax
for storage of raw and normalised microarray datasets
- Completion of several larger mouse intervention studies
including the “Leiden“ study with genetically sensitised ApoE3Leiden
mice
- Microarray analysis of several large mouse and human studies
using the improved standardised microarray pipeline with
normalisation procedure and quality control
- Metabolomics analysis of all several large studies (Leiden
study, Human Pilot study)
- Identification of several gene polymorphisms associated with the
HYPLIP
sensitising genotype
- Improvement of microarray data analysis by combining several
bioinformatics
and pathway mining programs
- Employment of the FIAF-transgenic mouse as proof-of-principal
mouse model
for nutrigenomics research
- First identification of PPAR a as the hepatic sensor for
dietary fatty acids and further understanding of the PPAR a
-dependent transcriptome in liver and intestine
- Design and production of the NUGO mouse and human Affymetrix
oligonucleotide microarray with improved probe sets costing 30%
less than the 2.0 Affymetrix array